IMR Press / FBL / Volume 24 / Issue 3 / DOI: 10.2741/4730

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes

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1 Department of Experimental Surgery, Tangdu Hospital, Air Force Medical University, Xi’an, 710038, China
2 HemaCare Corporation, Van Nuys, CA 91504, USA
3 Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA
4 Department of Dermatology, Tangdu Hospital, Air Force Medical University, Xi’an, 710038, China
5 Department of Endocrinology, Xijing Hospital, Air Force Medical University, Xi’an, 710032, China
Front. Biosci. (Landmark Ed) 2019, 24(3), 482–493; https://doi.org/10.2741/4730
Published: 1 January 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Transforming growth factor beta (TGF-beta) and Chloride channel-3 (CLC-3) are critical for inflammatory response, cellular proliferation and apoptosis in hippocampus neurons. However, the relationship between CLC-3 and TGF-beta/TGF-beta Receptor II (RII) pathway in diabetic encephalopathy (DE) is unknown. In this study, both diabetes rat model and diabetes cell model were employed to elucidate the mechanisms involved. The increased expressions of CLC-3 and TGF- beta RII with cognitive impairment were observed in diabetic rats. The most obvious reduction on the survival of HT22 cells was at 10 ng/ml or 15 ng/ml TGF- beta stimulation, while the expressions of CLC-3 and TGF-beta RII were significantly increased under high glucose condition. Moreover, the study showed that CLC-3 antagonists had no apparent effect on up-regulated TGF- beta RII, but TGF- beta 1 inhibitors could reduce the up-regulated CLC-3 under high glucose. Results from the present study indicated that CLC-3 and TGF- beta signals might be related to cognitive disorders. The CLC-3 might be modulated by TGF- beta /TGF- beta RII signaling pathway during the development of DE.

Keywords
Diabetic rats
Learning
Memory
HT22
CLC-3
TGF-beta
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