IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4385

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Telomere and telomerase stability in human diseases and cancer

Show Less
1 Istituto di Genetica Molecolare, CNR, Via Abbiategrasso 207, 27100 Pavia, Italy
Academic Editor:Alejandro Bolzan
Front. Biosci. (Landmark Ed) 2016, 21(1), 203–224; https://doi.org/10.2741/4385
Published: 1 January 2016
(This article belongs to the Special Issue Telomeres and telomerase in genome instability)
Abstract

Telomeres are the nucleoprotein structures at the end of linear eukaryotic chromosomes required for genome stability. Telomerase is the specialized enzyme deputed to their elongation. Maintenance of a proper telomere structure, an accurate regulation of telomerase biogenesis and activity, as well as a correct telomere-telomerase interaction and a faithful telomeric DNA replication are all processes that a cell has to precisely control to safeguard its functionality. Here, we review key factors that play a role in the development of these processes and their relationship with human health.

Keywords
Telomere
Telomerase
Telomeric Proteins
TERC
TERT
Telomere Replication
Helicases
Telomere Fragility
Dyskeratosis Congenita
Cancer
Review
Share
Back to top