IMR Press / FBL / Volume 21 / Issue 1 / DOI: 10.2741/4377

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Lysophospholipids and their G protein-coupled receptors in atherosclerosis

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1 Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
2 Department of Nephrology and Hemodialysis Center, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China
3 Department of Nephrology and Hemodialysis Center, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 030012, China
Academic Editor:Xiao-Feng Yang
Front. Biosci. (Landmark Ed) 2016, 21(1), 70–88; https://doi.org/10.2741/4377
Published: 1 January 2016
(This article belongs to the Special Issue Amylin in vasodilation, energy expenditure and inflammation)
Abstract

Lysophospholipids (LPLs) are bioactive lipid-derived signaling molecules generated by the enzymatic and chemical processes of regiospecific phospholipases on substrates such as membrane phospholipids (PLs) and sphingolipids (SLs). They play a major role as extracellular mediators by activating G-protein coupled receptors (GPCRs) and stimulating diverse cellular responses from their signaling pathways. LPLs are involved in various pathologies of the vasculature system including coronary heart disease and hypertension (Table 1). Many studies suggest the importance of LPLs in their association with the development of atherosclerosis, a chronic and severe vascular disease. This paper focuses on the pathophysiological effects of different lysophospholipids on atherosclerosis, which may promote the pathogenesis of myocardial infarction and strokes. Their atherogenic biological activities take place in vascular endothelial cells, vascular smooth muscle cells, fibroblasts, monocytes and macrophages, dendritic cells, T-lymphocytes, platelets, etc.

Keywords
Lysophospholipids
G protein-coupled receptors
Vascular inflammation
Atherosclerosis
Review
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