IMR Press / FBL / Volume 20 / Issue 1 / DOI: 10.2741/4298

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The role of microRNAs in skeletal muscle health and disease

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1 Center for Muscle Biology, University of Kentucky, Lexington, KY, USA
2 Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA
Academic Editor:Amie J. Dirks-Naylor
Front. Biosci. (Landmark Ed) 2015, 20(1), 37–77; https://doi.org/10.2741/4298
Published: 1 January 2015
(This article belongs to the Special Issue Mechanisms of skeletal muscle dysfunction and preventative measures)
Abstract

Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ~ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.

Keywords
MyomiR
Exercise
Hypertrophy
Atrophy
Muscular dystrophy
Review
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