IMR Press / FBL / Volume 19 / Issue 7 / DOI: 10.2741/4271

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Emergence of life: from functional RNA selection to natural selection and beyond
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1 Division of Life Science and Applied Genomics Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, People's Republic of China
Academic Editor:David L. Abel
Front. Biosci. (Landmark Ed) 2014, 19(7), 1117–1150;
Published: 1 June 2014
(This article belongs to the Special Issue The transition from constraint to regulation at the origin of life)

This study tracks the rise, evolution and post-evolution of the genetic information system through emergence of life. The major stages traversed include prebiotic synthesis, functional RNA selection by metabolite, RNA World, peptidated RNA world, co-evolution of genetic code and amino acid biosynthesis, last universal common ancestor, Darwinian evolution and synthetic life.

Metabolic Expansion Law
RNA World
Peptidated RNA World
Coevolution Theory
Last Universal Common Ancestor
synthetic life
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