IMR Press / FBL / Volume 19 / Issue 6 / DOI: 10.2741/4258

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Amylin in vasodilation, energy expenditure and inflammation
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1 Department of Radiology, Norwalk Hospital, CT 06850, USA
Academic Editor:Xiao-Feng Yang
Front. Biosci. (Landmark Ed) 2014, 19(6), 936–944; https://doi.org/10.2741/4258
Published: 1 June 2014
(This article belongs to the Special Issue Amylin in vasodilation, energy expenditure and inflammation)
Abstract

Metabolic syndrome significantly increases the incidence of atherosclerosis-related diseases including coronary artery disease, stroke, and type 2 diabetes. Recent progress has demonstrated that amylin, or islet amyloid polypeptide, is circulating multifunctional hormone and neuropeptide, which is co-secreted with insulin into the bloodstream by pancreatic beta cells and plays a very important role in regulating feeding, energy homeostasis and inflammation. Recent FDA approval of amylin analog pramlintide as a new drug for treating type 1 and 2 diabetes positions amylin in the spotlight. In this analytical review, I summarize the recent progress on amylin studies in the following sections: 1) introduction to the molecular features of amylin; 2) amylin’s amyloidogenic and proinflammatory effects; 3) a satiety hormone and new drug in increasing energy expenditure; and 4) a vasodilator inducing hypotension and tachycardia; and 5) a neuropeptide in depolarizing cholinergic neurons via closure of potassium channels. Continued improvement of our understanding on this multifunctional hormone would lead to future development of pramlintide as novel therapies for other inflammatory, hematological, metabolic, neurological and vascular diseases.

Keywords
Amylin
Islet Amyloid Polypeptide
IAPP
Neuropeptide
Inflammation
Energy Metabolism
Review
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