IMR Press / FBL / Volume 18 / Issue 4 / DOI: 10.2741/4174

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Approaches on genetic polymorphism of Cryptococcus Species Complex

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1 Department of Dermatology, Shanghai Key Laboratory of Molecular Mycology & PLA Key Laboratory of Fungal Diseases, ChangZheng Hospital Second Military Medical University, Shanghai, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2013, 18(4), 1227–1236;
Published: 1 June 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)

The Cryptococcus species complex is the significant pathogenic fungi that result in over 1 million cases of cryptococcosis each year in the world. Proper strategy for genetic polymorphism study of the Cryptococcus species complex is crucial to unfold genetic population structure, spread profile and pathogenicity of these pathogenic yeasts worldwide. Currently, an array of approaches, including serotype, PCR fingerprinting, amplified fragment length polymorphisms (AFLP), analysis of DNA sequence, and matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF MS) etc. improved our understanding of genetic diversity or phylogenetic of Cryptococcus species complex. This review synthesizes existing techniques of cryptococcal genetic polymorphism and raises issues that remain to be addressed.

Cryptococcus Species Complex; Genetic Diversity; Molecular Approach; Advance
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