IMR Press / FBL / Volume 18 / Issue 3 / DOI: 10.2741/4168

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Ligands and receptors of lung surfactant proteins SP-A and SP-D

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1 Department of Pharmacology, University of Oxford, Mansfield Rd, Oxford OX1 3QT, UK
2 MRC Immunochemistry Unit, Department of Biochemistry, South Parks Rd, Oxford,OX1 3QU, UK
3 Centre for Infection, Immunity and Disease Mechanisms, Heinz Wolff Building, Brunel University, London UB8 3PH, UK
Academic Editor:Uday Kishore
Front. Biosci. (Landmark Ed) 2013, 18(3), 1129–1140;
Published: 1 June 2013
(This article belongs to the Special Issue Pulmonary surfactant in human health and disease)


Surfactant Protein A (SP-A) and D (SP-D) are calcium-dependent collagen-containing lectins, also called collectins, which play a significant role in surfactant homeostasis and pulmonary immunity. The role of SP-A and SP-D in immune defence is well- established. They are known to bind to a range of microbial pathogens that invade the lungs and target them for phagocytic clearance by resident alveolar macrophages. They are also involved in the clearance of apoptotic and necrotic cells and subsequent resolution of pulmonary inflammation. To date, the molecular mechanisms by which SP-A and SP-D interact with various immune cells are poorly understood. In spite of overall structural similarity, SP-A and SP-D show a number of functional differences in their interaction with surface molecules of microorganisms and host cells. The aim of this review is to provide an overview of the current knowledge of ligands and receptors that are known to interact with SP-A and SP-D.

Lung Surfactant Proteins
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