IMR Press / FBL / Volume 17 / Issue 4 / DOI: 10.2741/3995

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Molecular mechanisms of natural killer cell regulation
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1 Institute for Immunology, University Heidelberg, INF 305, 69120 Heidelberg, Germany
2 Leibniz Research Center for Working Environment and Human Factors–IfADo, Ardeystrasse 67, 44139 Dortmund, Germany

Academic Editor: Wolfgang Schamel

Front. Biosci. (Landmark Ed) 2012, 17(4), 1418–1432;
Published: 1 January 2012
(This article belongs to the Special Issue Systems immunology)

Natural Killer (NK) cells are important for early immune reactions against viral infections and cancer. They are regulated by a highly redundant system of different activating and inhibitory receptors. Here we summarize our current understanding about the regulation of these cells and describe how mathematical modeling and systems biology approaches can help to shed some light on the complex regulatory network that governs NK cell reactivity.

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