IMR Press / FBL / Volume 17 / Issue 3 / DOI: 10.2741/3977

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis
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1 Moores Cancer Center, Department of Pathology and Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Front. Biosci. (Landmark Ed) 2012, 17(3), 1120–1139; https://doi.org/10.2741/3977
Published: 1 January 2012
Abstract

RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis. RUNX1 is also integral in defining the definitive hematopoietic stem cell. In addition, many hematological diseases like myelodysplastic syndrome and myeloproliferative neoplasms have been associated with mutations in RUNX1. Located on chromosomal 21, the RUNX1 gene is involved in many forms of chromosomal translocations in leukemia. t(8;21) is one of the most common chromosomal translocations found in acute myeloid leukemia (AML), where it results in a fusion protein between RUNX1 and ETO. The RUNX1-ETO fusion protein is found in approximately 12% of all AML patients. In this review, we detail the structural features, functions, and models used to study both RUNX1 and RUNX1-ETO in hematopoiesis over the past two decades.

Keywords
RUNX1
AML1
CBFA2
RUNX1-ETO
AML1-ETO
RUNX1-RUNX1T1
Hematopoiesis
Hematopoietic Stem Cells
Leukemia
AML
Leukemogenesis
Mouse Models
Review
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