IMR Press / FBL / Volume 16 / Issue 8 / DOI: 10.2741/3894

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice
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1 Department of emergency and critical care medicine, Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China
2 Department of intensive care unit, Jiangsu University affiliated Jintan Hospital, Jintan, Jiangsu Province, 213200, China
3 Department of emergency, the 306th Hospital of PLA, Beijing, 100101, China
Academic Editor:Jie Zou
Front. Biosci. (Landmark Ed) 2011, 16(8), 3004–3013; https://doi.org/10.2741/3894
Published: 1 June 2011
(This article belongs to the Special Issue Immunoregulation and inflammatory disease)
Abstract

Tregs are involved in immune disorder during sepsis; they can lead to a Th2 immune reaction. Their inhibitory effects can help alleviate inflammatory injury, but may also cause secondary immune inhibition. Thymosin-alpha1 is a polypeptide with powerful immunomodulatory activities. Current reports have shown that Thymosin-alpha1 conferred beneficial effects to septic patients. To explore the relationship between Thymosin-alpha1 and Tregs, in this study, we investigated the changing trend in CD4+CD25+Foxp3+ T lymphocytes in a CLP septic mouse model. We also investigated the variation of apoptotic rate of CD4+CD25+ T lymphocytes, cytokine variation, and change of model survival rate when Thymosin-alpha1 intervening or not. We observed that the 72-h survival rate was improved, the percentage of CD4+CD25+Foxp3+ T lymphocytes decreased and the apoptosis rate of CD4+CD25+ T lymphocytes increased after intervention of Thymosin-alpha1. At same time the expression of pro-inflammation cytokines IL-2, TNF-alpha and anti-inflammatory cytokines IL-10 and TGF-beta were regulated. In conclusion, Thymosin-alpha1 can effectively control the inflammatory response intensity and improve the 72-h survival rate of septic mice. Regulating Tregs may be another important role of Thymosin-alpha1 conditioning the immune reaction in sepsis.

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