IMR Press / FBL / Volume 16 / Issue 6 / DOI: 10.2741/3852

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
RAS and Hedgehog--partners in crime
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1 Institute of Molecular Biology and Tumor Research (IMT), Philipps University, 35037 Marburg, Germany

Academic Editor: Takashi Shimokawa

Front. Biosci. (Landmark Ed) 2011, 16(6), 2259–2270;
Published: 1 June 2011
(This article belongs to the Special Issue Hedgehog signaling)

Both RAS and Hedgehog (HH) pathway activation can be found in approximately one third of all cancers. In many cases, this activation occurs in the same tumor types, suggesting a positive impact of a simultaneous activation of RAS and HH on tumor development. This review aims to summarize the current knowledge about the molecular and functional crosstalk of RAS and HH signaling in the development of hyperproliferative disease.

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