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Article
RAS and Hedgehog--partners in crime
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1
Institute of Molecular Biology and Tumor Research (IMT), Philipps University, 35037 Marburg, Germany
Front. Biosci. (Landmark Ed) 2011, 16(6), 2259–2270;
https://doi.org/10.2741/3852
Published: 1 June 2011
Abstract
Both RAS and Hedgehog (HH) pathway activation can be found in approximately one third of all cancers. In many cases, this activation occurs in the same tumor types, suggesting a positive impact of a simultaneous activation of RAS and HH on tumor development. This review aims to summarize the current knowledge about the molecular and functional crosstalk of RAS and HH signaling in the development of hyperproliferative disease.