IMR Press / FBL / Volume 16 / Issue 4 / DOI: 10.2741/3790

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Signalling pathways and vascular calcification
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1 Cardiovascular Division, King's College London, 125 Coldharbour Lane SE5 9NU, London

Academic Editor: Tao Wang

Front. Biosci. (Landmark Ed) 2011, 16(4), 1302–1314; https://doi.org/10.2741/3790
Published: 1 January 2011
(This article belongs to the Special Issue Signalling pathways in cardiovascular function and diseases)
Abstract

Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. A full understanding of the signalling pathways mediating vascular calcification is crucial not just because of the importance of this pathology in disease, but also for exploring potential therapeutic targets. Clinically there is a need to develop therapies to prevent or even reverse calcification in situations of atherosclerosis, chronic kidney disease, diabetes, and aging. In this brief review, we intend to explore the initial triggers, which are commonly related to calcification in different disease scenarios and examine the downstream signalling pathways that instigate the process of vascular calcification. In particular, we try to dissect these pathways and also examine cross-talk between different signalling pathways. Our focus is the vascular smooth muscle cell (VSMC) as it is ultimately the phenotypic modulation of these cells that may drive the calcification process.

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