IMR Press / FBL / Volume 14 / Issue 9 / DOI: 10.2741/3471

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The mitochondrial outer membrane protein import machinery: a new player in apoptosis?
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1 Equipe 9, Centre de Recherche en Cancerologie Nantes-Angers (U892 INSERM), Nantes, cedex 01, France
2 Faculty of Medicine, University of Nantes, 9 quai Moncousu, 44035 Nantes, cedex 01, France

Academic Editor: Catherine Brenner

Front. Biosci. (Landmark Ed) 2009, 14(9), 3563–3570; https://doi.org/10.2741/3471
Published: 1 January 2009
(This article belongs to the Special Issue Apoptosis and mitochondria)
Abstract

The proteins of the BCL-2 family (pBCL-2s) are involved in the sequence of events that culminates in apoptosis, a type I cell death program. The mitochondrion is the primary site of action of pBCL-2s and represents the cross roads between the initiation and the execution phases of apoptosis. pBCL-2s are either constitutively associated with the mitochondria outer membrane (MOM) or targeted to this membrane at the onset of apoptosis. The mechanisms implicated in their targeting and activation during apoptosis is largely unknown. Recently, several pBCL-2s have been shown to interact with components of the translocase of the outer membrane (TOM), a complex responsible for the import into and across the MOM of nuclear encoded mitochondrial proteins. Here we will review the available data and discuss the possible implications of this interaction in the apoptotic programme.

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