IMR Press / FBL / Volume 14 / Issue 8 / DOI: 10.2741/3430

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Regulation of asymmetric stem cell division: spindle orientation and the centrosome
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1 Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI
2 Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI
Front. Biosci. (Landmark Ed) 2009, 14(8), 3003–3011; https://doi.org/10.2741/3430
Published: 1 January 2009
Abstract

Asymmetric stem cell division, as a means of maintaining adequate numbers of stem cells, has attracted widespread attention from researchers in the stem cell biology field. Yet, the molecular and cellular mechanisms that govern asymmetric stem cell division remain poorly understood. Stem cells are not the only cell population that divides asymmetrically, and fortunately, great progress has been made in the understanding of asymmetric cell division during development, providing insight into strategies that stem cells may employ to divide asymmetrically. This review will summarize the importance of stem cell function and the role of asymmetric division in controlling stem cell behavior.

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