IMR Press / FBL / Volume 14 / Issue 7 / DOI: 10.2741/3393

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cathepsin S and its inhibitor cystatin C: imbalance in uveal melanoma
Show Less
1 Unit of Ophthalmology, School of Clinical Science, University of Liverpool, Liverpool, UK
2 Department of Pathology, Royal Liverpool University Hospital, Liverpool, UK
3 Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, UK
4 Ocular Oncology Centre, St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK
Front. Biosci. (Landmark Ed) 2009, 14(7), 2504–2513;
Published: 1 January 2009

The present study aimed to investigate, as a follow-up of microarray profiling, the expression of the lysosomal cysteine protease cathepsin S and that of its endogenous inhibitor cystatin C in the most common primary intraocular tumor in adults, uveal melanoma. The expression pattern unveiled was characterized by a relative increase in the active form of the elastolytic and collagenolytic cathepsin S that was not counterbalanced by the expression of its strongest endogenous inhibitor cystatin C in the aggressive, highly metastatic uveal melanomas. The study provides evidence for a novel correlation between a specific cysteine protease activity and the strongest predictive factor for metastatic behavior in primary uveal melanoma and documents the first investigation of both a specific protease activity and its endogenous inhibitor in uveal melanoma. The results indicate that the shift in the balance between cathepsin S and cystatin C may be part of deregulated proteolytic pathways contributing to the invasive phenotype of uveal melanoma.

Back to top