IMR Press / FBL / Volume 14 / Issue 6 / DOI: 10.2741/3370

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Apoptotic signaling cascades operating in poliovirus-infected cells
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1 Biologie des Virus Enteriques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, France
2 INSERM U841, 94010 Creteil, France
Academic Editor:Catherine Brenner
Front. Biosci. (Landmark Ed) 2009, 14(6), 2181–2192; https://doi.org/10.2741/3370
Published: 1 January 2009
(This article belongs to the Special Issue Apoptosis and mitochondria)
Abstract

The flaccid paralyses characteristic of poliomyelitis are a direct consequence of the infection of motor neurons with poliovirus (PV). In PV-infected mice, motor neurons die by apoptosis. However, the mechanisms by which PV induces cell death in neurons remain unclear. Analyses of the apoptotic pathways induced by PV infection in several cell lines have demonstrated that mitochondria play a key role in PV-induced apoptosis. Furthermore, mitochondrial dysfunction results from an imbalance between pro- and anti-apoptotic pathways. We present here an overview of the many studies of PV-induced apoptosis carried out in recent years and discuss the contribution of these studies to our understanding of poliomyelitis.

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