IMR Press / FBL / Volume 14 / Issue 3 / DOI: 10.2741/3302

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
PML nuclear bodies and their spatial relationships in the mammalian cell nucleus
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1 Macromolecular Structure and Function Lab, Division of Molecular Biosciences, Imperial College London, Biochemistry Building, South Kensington Campus, London, SW7 2AZ, U.K
Academic Editor:Katherine Borden
Front. Biosci. (Landmark Ed) 2009, 14(3), 1182–1196; https://doi.org/10.2741/3302
Published: 1 January 2009
Abstract

Promyelocytic leukaemia nuclear bodies (PML NBs) are found within the nucleus of mammalian cells, and are formed from the constituent proteins PML and Sp100. Numbering between 10 and 30 per cell, they are an obvious feature of the nuclear landscape, yet their functions have still to be unambiguously defined. In the mammalian nucleus, compartmentalization of functions is apparent, as reflected in the wide-range of other nuclear compartments that can be identified. These include nucleoli, transcription foci, splicing speckles, chromosomal topological markers such as centromeres and telomeres, the nuclear boundary, and the nucleoplasm itself. Quantification of the otherwise qualitative observations of relationships between mammalian nuclear compartments is essential for a complete understanding of nuclear processes. Here we describe some of the interesting known associations between PML NBs and other nuclear compartments, and comment upon their implications for PML NB function.

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