IMR Press / FBL / Volume 14 / Issue 3 / DOI: 10.2741/3293

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Bone cells-biomaterials interactions
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1 Laboratory of Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Chemical Engineering Department, 2500, Universite Blvd, Sherbrooke, Quebec, J1K 2R1, Canada
2 Centre Hospitalier Universitaire de Sherbrooke, Faculty of Life Sciences and Medicine, Surgery Department, 3001, 12e Avenue Nord, Sherbrooke, Quebec, J1H 5N4, Canada
Academic Editors:Patrick Vermette, Jonathan Lakey, Rennian Wang, Steven Paraskevas
Front. Biosci. (Landmark Ed) 2009, 14(3), 1023–1067; https://doi.org/10.2741/3293
Published: 1 January 2009
Abstract

With the aging population, the incidence of bone defects due to fractures, tumors and infection will increase. Therefore, bone replacement will become an ever bigger and more costly problem. The current standard for bone replacement is autograft, because these transplants are osteoconductive and osteoinductive. However, harvesting an autograft requires additional surgery at the donor site that is related to high level of morbidity. In addition, the quantity of bone tissue that can be harvested is limited. These limitations have necessitated the pursuit of alternatives using biomaterials. The control of bone tissue cell adhesion to biomaterials is an important requirement for the successful incorporation of implants or the colonization of scaffolds for tissue repair. Controlling cells-biomaterials interactions appears of prime importance to influence subsequent biological processes such as cell proliferation and differentiation. Therefore, interactions of cells with biomaterials have been widely studied especially on two-dimensional systems. This review focuses on these interactions.

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