IMR Press / FBL / Volume 14 / Issue 14 / DOI: 10.2741/3597

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Regulation of hematopoietic cell development and function by Stat3
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1 Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802

Academic Editor: Kevin Bunting

Front. Biosci. (Landmark Ed) 2009, 14(14), 5273–5290; https://doi.org/10.2741/3597
Published: 1 June 2009
(This article belongs to the Special Issue JAKSTAT signaling in hematopoiesis)
Abstract

Activation of the Jak/Stat pathway plays a central role in hematopoietic development. Here, we focus on unique functions for Stat3 in the development of the hematopoietic system. Recent studies highlight a critical role for Stat3 in the development of T helper cell and B cell subsets as well as dendritic cell development and maturation. Further, Stat3 appears to play an important function in limiting neutrophil numbers and in regulating hematopoietic stem cell self-renewal. In macrophages, Stat3 is essential in limiting TLR signaling and the inflammatory damage associated with classical macrophage activation. Stat3 also plays an essential role in leukemic development induced by viral oncogenes, chromosomal translocations and by the Friend erythroleukemia virus. We also discuss the mechanism by which Stat3 is activated by extracellular signals, and the current understanding of the role of post-translational modification in the regulation of Stat3 activity. Understanding the molecular events underlying Stat3 activation will be critical in generating targeted therapeutics aimed at modulating Stat3 function.

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