IMR Press / FBL / Volume 14 / Issue 13 / DOI: 10.2741/3584

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Replication licensing and the DNA damage checkpoint
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1 Department of Biochemistry and Biophysics and Department of Pharmacology, Lineberger Comprehensive Cancer Center Campus Box 7260, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Academic Editor: Howard Kaufman

Front. Biosci. (Landmark Ed) 2009, 14(13), 5013–5030;
Published: 1 June 2009
(This article belongs to the Special Issue Cancer vaccine)

Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with processes that ensure genome integrity. Significant advances in determining how the earliest steps in DNA replication are affected by DNA damage have highlighted some of the mechanisms to establish that coordination. Recent insights have expanded the relationship between the ATM and ATR-dependent checkpoint pathways and the proteins that bind and function at replication origins. These findings suggest that checkpoints and replication are more intimately associated than previously appreciated, even in the absence of exogenous DNA damage. This review summarizes some of these developments.

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