IMR Press / FBL / Volume 13 / Issue 9 / DOI: 10.2741/2945

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Neurotoxic effects of antineoplastic drugs: the lesson of pre-clinical studies
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1 Department of Neurosciences and Biomedical Technologies, University of Milan “Bicocca”, Monza, Italy

*Author to whom correspondence should be addressed.

Academic Editor: Haseeb Ahmad Khan

Front. Biosci. (Landmark Ed) 2008, 13(9), 3506–3524;
Published: 1 May 2008
(This article belongs to the Special Issue Molecular biology in clinical practice)

Several antineoplastic drugs induce severe toxic damage of the peripheral nervous system and chemotherapy-induced peripheral neurotoxicity (CIPN) can be dose limiting. Moreover, CIPN signs and symptoms can be permanent and severely impair the patients' quality of life even after drug withdrawal. Despite extensive investigation, the exact mechanisms of neurotoxic action at the basis of CIPN are not completely known and it is likely that they can be at least in part different from the mechanisms of antineoplastic action of the drugs. A possible instrument to investigate on this important issue is represented by the evaluation of the effect of compounds used to reduce the toxicity of antineoplastic drugs in pre-clinical and clinical settings. This review will be focused on the most clinically-relevant neurotoxic antineoplastic drugs and on the results obtained with several different classes of putative neuroprotectants.

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