Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
T cell antigen recognition is a special process. The complicated bindings between T cell receptor (TCR) or co-receptor (CD4 or CD8) and antigen peptide-major histocompatibility complex (pMHC) molecules have specific physiological significance. Recent reports show that different recognition models do exist in recognizing pMHCs by a single T cell. These different recognition mechanisms allow a single T cell to identify 'self' from 'non-self' and result in different biological consequence.