Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
The discovery of regulatory networks is an important aspect in the post genomic research. The process requires integrated efforts of experimental and computational strategies by employing the systems biology approach. This review summarizes some of the major themes in computational inference of regulatory networks based on gene expression and other data sources, including transcriptional module identification, network topology inference, and network analysis. Popular solutions to each of these problems and their relative merits are discussed.