IMR Press / FBL / Volume 12 / Issue 3 / DOI: 10.2741/2107

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The GCK II and III subfamilies of the STE20 group kinases
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1 Department of Physiology, School of Medicine, University of Santiago de Compostela, A Coruña, Spain
2 Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
3 Molecular Cardiology Research Institute, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Academic Editor:Vicente Andres
Front. Biosci. (Landmark Ed) 2007, 12(3), 850–859;
Published: 1 January 2007

The Ste20 (sterile 20) proteins are a large family of serine/threonine kinases. Since their discovery a growing body of evidence has implicated them in the regulation of signaling pathways governing cell growth, cell differentiation cell death and cell volume. Approximately 30 human members have been identified based on the high degree of homology of their catalytic domain to that of the Ste20p from Saccharomyces cerevisiae. In addition to the conserved regions, there are also regions of sequence that make each of them unique. In this review we will focus on two subfamilies of the group, GCK-II and GCK-III, families that are closely related but, again, unique in their structural features and biological functions. Herein, we will present what we hope will be the current state of knowledge about these kinases, and discuss what remains to be done in order to better understand their activity and regulation.

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