IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1657

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Angiogenesis in rheumatoid arthritis
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1 Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H-4004, Hungary
2 Department of Orthopedics, University of Debrecen Medical and Health Sciences Center, Debrecen, H-4004, Hungary
3 University of Michigan Health System, Department of Internal Medicine, Division of Rheumatology, Ann Arbor, MI

Academic Editor: Joseph Holoshitz

Front. Biosci. (Landmark Ed) 2005, 10(2), 1739–1753;
Published: 1 May 2005
(This article belongs to the Special Issue The pathogenesis of rheumatoid arthritis)

Endothelial cells lining the lumina of blood vessels are involved in leukocyte extravasation underlying inflammatory states, such as rheumatoid arthritis (RA). New vessel formation, termed angiogenesis, is also crucial for leukocyte extravasation during inflammatory synovitis. The outcome of neovascularization in the RA synovium is highly dependent on the balance or imbalance between angiogenic mediators and inhibitors. There have been several attempts to therapeutically interfere with the cellular and molecular mechanisms underlying RA-associated neovascularization. Most studies have been performed using animal models of arthritis. In addition, a limited number of human clinical trials gave promising results. In this review, authors summarize some relevant information on those angiogenic and angiostatic agents, which have also been studied in context with RA. In addition, further perspectives of anti-angiogenic therapy in arthritis are also discussed. Specific targeting of angiogenesis may be useful in the future management of various inflammatory, as well as malignant, diseases.

Rheumatoid Arthritis
Endothelial Cells
Angiogenic Mediators
Angiostatic Compounds
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