IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1606

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Transforming growth factor -beta receptor signaling in cancer
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1 Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA

Academic Editor: Sushanta K. Banerjee

Front. Biosci. (Landmark Ed) 2005, 10(2), 1135–1145; https://doi.org/10.2741/1606
Published: 1 May 2005
(This article belongs to the Special Issue Growth factors and cancer)
Abstract

Transforming growth factor-beta (TGF-beta) is an ubiquitous cytokine that affects various biological processes, such as regulation of cell proliferation, immune responses, growth, differentiation, angiogenesis, and apoptosis of various cell types. The TGF-beta ligand initiates signaling by binding to and joining type I and II receptors of serine/threonine kinases. This review discusses the TGF-beta ligands and receptors, its positive and negative regulators in signaling, as well as its important roles with respect to tumor suppression and progression.

Keywords
Apoptosis
Ligands
Receptors
Ski
I-Smads
Smads
Transforming growth factor beta
Tumor suppressor
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