IMR Press / FBL / Volume 10 / Issue 2 / DOI: 10.2741/1606

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Transforming growth factor -beta receptor signaling in cancer
Show Less
1 Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA

Academic Editor: Sushanta K. Banerjee

Front. Biosci. (Landmark Ed) 2005, 10(2), 1135–1145;
Published: 1 May 2005
(This article belongs to the Special Issue Growth factors and cancer)

Transforming growth factor-beta (TGF-beta) is an ubiquitous cytokine that affects various biological processes, such as regulation of cell proliferation, immune responses, growth, differentiation, angiogenesis, and apoptosis of various cell types. The TGF-beta ligand initiates signaling by binding to and joining type I and II receptors of serine/threonine kinases. This review discusses the TGF-beta ligands and receptors, its positive and negative regulators in signaling, as well as its important roles with respect to tumor suppression and progression.

Transforming growth factor beta
Tumor suppressor
Back to top