IMR Press / FBL / Volume 1 / Issue 3 / DOI: 10.2741/A109

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

SOLID PHASE PURIFICATION AND SSCP ANALYSIS OF AMPLIFIED
GENOMIC DNA BY CAPILLARY ELECTROPHORESIS

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1 Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche Avanzate, L.I.T.A., Via Fratelli Cervi 93, 20090 Segrate, ITALY
Front. Biosci. (Landmark Ed) 1996, 1(3), 1–3; https://doi.org/10.2741/A109
Published: 1 January 1996
Abstract

Detection and identification of point mutations in genomic DNA has proven increasingly important in biomedical research. A variety of methods for the analysis of single base substitutions have been proposed among which Single Strand Conformational Polymorphism (SSCP) quickly gained success due to its simplicity. In this work we present an analytical on-line tool which combines the ease of solid phase purification of amplified genomic DNA, the simplicity of SSCP and the significant potential advantages offered by capillary electrophoresis (CE).

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