IMR Press / CEOG / Volume 42 / Issue 1 / DOI: 10.12891/ceog1798.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The outcome and course of pregnancies complicated with fetal neural tube defects
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1 Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade
2 Faculty of Medicine, University of Belgrade, Belgrade
3 Clinic for Gynecology and Obstetrics, Narodni front, Belgrade (Serbia)
Clin. Exp. Obstet. Gynecol. 2015, 42(1), 57–61; https://doi.org/10.12891/ceog1798.2015
Published: 10 February 2015
Abstract
Purpose: The objectives of this study were as follows: to present the course and outcome of pregnancies complicated with neural tube defects, determine the association between prenatal ultrasound diagnoses, and definitive diagnoses after autopsy. Matherial and Methods: The survey was designed as a retrospective study and included 24 pregnant women who were attending a regular ultrasound examinations at the Department of Gynecology and Obstetrics, Clinical Center of Serbia, or patients who were referred from other institutions in Serbia. Results: Neural tube defects are divided into five subgroups: spina bifida, meningocele, myelomeningocele, acranius, and anencephaly. The most frequent in the present study was spina bifida with 67%. All pregnancies complicated with neural tube defects were terminated. Conclusion: Their clinical severity and uncertain cause make them priorities for further research, whether to better target primary preventive measures, to improve in-utero surgery for prenatal repair, or to identify the causative genes to provide an objective basis for individual genetic counselling.
Keywords
Neural tube defects
Fetus
Outcome
Pregnancy
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