IMR Press / CEOG / Volume 42 / Issue 1 / DOI: 10.12891/ceog1853.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The effect of calcium channel blockers on prevention of preeclampsia in pregnant women with chronic hypertension
N. Jiang1Q. Liu1, L. Liu1,*W.W. Yang2Y. Zeng3
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1 Department of Obstetrics and Gynecology, The First People’s Hospital of Kunshan affiliated with Jiangsu University, Suzhou
2 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou
3 Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing (China)
Clin. Exp. Obstet. Gynecol. 2015, 42(1), 79–81; https://doi.org/10.12891/ceog1853.2015
Published: 10 February 2015
Abstract
Background: Pregnant women with chronic hypertension are at increased risk for complications. This study aims to investigate whethercalcium channel blockers plus low dosage aspirin therapy can reduce the incidence of complications during pregnancy with chronic hypertensionand improve the prognosis of neonates. Materials and Methods: From March 2011 to June 2013, 33 patients were selected tojoin this trial according to the chronic hypertension criteria set by the Preface Bulletin of American College of Obstetricians and Gynecologists, (ACOG). Patients were administrated calcium channel blockers plus low-dosage aspirin and vitamin C. The statistic data of baselineand prognosis from the patients were retrospectively reviewed and compared. Results: Blood pressure of patients was controlled bythese medicines with average systolic pressure from 146.3 to 148.7 mmHg and average diastolic pressure from 93.8 to 97.9 mmHg;39.4% patients complicated mild preeclampsia; however, none of them developed severe preeclampsia or eclampsia, or complicate placentalabruption. 30.3% patients delivered at preterm labour; 84.8% patients underwent cesarean section. The neonatal average weightwas 3,008 ± 629.6 g, in which seven neonatal weights were less than 2,500 g. All of the neonatal Apgar scores were 9 to 10 at one to fiveminutes. Small for gestational age (SGA) occurred in five (15%). Conclusions: Calcium channel blockers can improve the outcome ofpregnancy women with chronic hypertension to avoid the occurrence of severe pregnancy complication or neonatal morbidity.
Keywords
Preeclampsia
Chronic hypertension
Calcium channel blockers
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