IMR Press / RCM / Volume 3 / Issue S2 / pii/1561516730403-1051050874

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Therapeutic Agents—Pharmacokinetics and Pharmacodynamics
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1 Division Hematology, Department of Medicine,The Johns Hopkins University School of Medicine, Baltimore, MD
Rev. Cardiovasc. Med. 2002, 3(S2), 34–44;
Published: 20 February 2002
Various thrombolytic agents have been studied as activators of the plasminogen-plasmin system for thrombolysis of thrombus formation. They include streptokinase, urokinase, tissue plasminogen activators, single-chain urokinase plasminogen activator, and anisoylated or acylated plasminogen-streptokinase activator complex (APSAC), only some of which are commercially available. All thrombolytic agents, including APSAC (not commercially available), recombinant tissue plasminogen activator, and prourokinase, generate great quantities of degradation products of fibrinogen or fibrin. All of the second-generation thrombolytic agents induce systemic activation of the entire fibrinolytic system, and none are capable of specifically activating the fibrinolytic system at the site of thrombus formation. The most systemically active agent known at the present time is APSAC. Trials show that bleeding occurs as frequently with the second-generation agents as with the older agents, and further studies may even find that the newer agents are associated with more bleeding than urokinase and streptokinase have been. With knowledge of the properties of the various thrombolytic agents available today, the physician can intelligently select the optimal agent for a given patient problem.
Thrombolytic agents
Plasminogen-plasmin proteolytic enzyme system
Plasminogen activators
Fibrinolytic system
Fibrin degradation products
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