IMR Press / JIN / Volume 21 / Issue 2 / DOI: 10.31083/j.jin2102056
Open Access Original Research
Diagnosis of Alzheimer's disease by feature weighted-LSTM: a preliminary study of temporal features in brain resting-state fMRI
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1 School of Computer Science and Technology, Donghua University, 201620 Shanghai, China
*Correspondence: (Chen Qian)
Academic Editor: François S. Roman
J. Integr. Neurosci. 2022, 21(2), 56;
Submitted: 16 June 2021 | Revised: 24 August 2021 | Accepted: 31 August 2021 | Published: 22 March 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

The long short-term memory network (LSTM) is widely used in time series data processing as a temporal recursive network. The resting-state functional magnetic resonance data shows that not only are there temporal variations in the resting state, but there are also interactions between brain regions. To integrate the temporal and spatial characteristics of brain regions, this paper proposes a model called feature weighted-LSTM (FW-LSTM). The feature weight is defined by spatial characteristics calculating the frequency of connectivity of each brain region and further integrated into the LSTM. Thus, it can comprehensively model both temporal and spatial changes in rs-fMRI brain regions. The FW-LSTM model on the Alzheimer’s disease neuroimaging initiative (ADNI) dataset is used to extract the time-varying characteristics of 90 brain regions for Alzheimer’s disease (AD) classification. The model performances are 77.80%, 76.41%, and 78.81% in accuracy, sensitivity, and specificity. It outperformed the one-dimensional convolutional neural networks (1D-CNN) model and LSTM model, which only used temporal features of brain regions.

Rs-fMRI data
Temporal characteristics
Spatial characteristics
Fig. 1.
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