IMR Press / JIN / Volume 20 / Issue 2 / DOI: 10.31083/j.jin2002052
Open Access Commentary
Clinical utility of degradomics as predictors of complications and clinical outcome in aneurysmal subarachnoid hemorrhage
Show Less
1 Department of Neurosurgery, American University of Beirut Medical Center, 2033 9105 Beirut, Lebanon
2 Faculty of Medicine, Lebanese University, 2033 9105 Beirut, Lebanon
3 Department of Neurosurgery, Johns Hopkins School of Medicine, 21202 Baltimore, Maryland
4 Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77002, USA
*Correspondence: (Ibrahim Omeis)
J. Integr. Neurosci. 2021, 20(2), 489–497;
Submitted: 28 January 2021 | Revised: 9 February 2021 | Accepted: 24 March 2021 | Published: 30 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Most of the debilitating conditions following aneurysmal subarachnoid hemorrhage result from symptomatic cerebral vasospasm and delayed cerebral ischemia. Several scales are being used, but they still lack objectivity and fail to quantify complications considered essential for prognostication routine use of biomarkers to predict complications and outcomes after aneurysmal rupture is still experimental. Degradomics were studied extensively in traumatic brain injury, but there is no discussion of these biomarkers related to aneurysmal subarachnoid hemorrhage. Degradomics involve the activation of proteases that target specific substrates and generate specific protein fragments called degradomes. While the proteolytic activities constitute the pillar of development, growth, and regeneration of tissues, dysregulated proteolysis resulting from pathological conditions like aneurysmal subarachnoid hemorrhage ends up in apoptotic processes and necrosis. To our knowledge, this is the first overview that lists a panel of degradomics with cut-off values in serum and cerebrospinal fluid, where specificity and sensitivity are only found in Kallikrein 6, Ubiquitin C Terminal Hydrolase 1 and Alpha-II-Spectrin.

Subarachnoid hemorrhage
Blood-brain barrier
Fig. 1.
Back to top