Dear Colleagues,

Cardiovascular diseases (CVD) are the leading cause of mortality worldwide. Acute coronary syndrome accounting for a large part of the mortality burden related to CVD. Recent years have witnessed amazing progress in this field, with key discoveries in basic mechanisms, clinical pathophysiology and biomarkers leading to a consistent improvement in patient treatments. Despite this, residual risk remains a challenge even with optimal management.

This special issue focuses on current gaps and possible solutions in the field of Acute Coronary Syndrome. Novel research approaches such as multi-omics, personalized medicine and artificial intelligence are leveraging recent and ongoing achievements in this field, including new drug treatments for dyslipidemia and antithrombotic drugs to support LV function, into a unique and unprecedented opportunity.

We welcome the submission of original research and review articles on pertinent topics, including:

- Molecular mechanisms underlying atherosclerosis and the development of acute coronary syndromes;

- Cardiovascular risk stratification and the prevention of acute coronary syndrome;

- Treatment of acute coronary syndrome;

- Intracoronary diagnostics for the management of patients with acute coronary syndrome;

- Acute coronary syndrome (ACS) in special populations (young patients, elderly, diabetics, achd);

- ACS without obstructive coronary artery disease (ACS-NNOCA);

- Personalized medicine and Artificial Intelligence in ACS.

Prof. Salvatore De Rosa

Guest Editor