IMR Press / RCM / Volume 25 / Issue 4 / DOI: 10.31083/j.rcm2504134
Open Access Review
Mitral Regurgitation and Left Ventricular Outflow Tract Obstruction: Confluence of Challenges for Transcatheter Treatment
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1 Department of Cardiology, University Hospital Alvaro Cunqueiro, 36312 Vigo, Spain
2 Cardiovascular Research Group, Department of Cardiology, University Hospital Alvaro Cunqueiro, Galicia Sur Health Research Institute (IIS Galicia Sur), Servizo Galego de Saude, University of Vigo, 36312 Vigo, Spain
*Correspondence:; (Rodrigo Estévez-Loureiro)
Rev. Cardiovasc. Med. 2024, 25(4), 134;
Submitted: 6 November 2023 | Revised: 23 January 2024 | Accepted: 29 January 2024 | Published: 3 April 2024
(This article belongs to the Special Issue New Perspectives of Valvulopathy)
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

The intricate interplay between mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction may result in two clinical scenarios: prosthesis-related LVOT obstruction after mitral valve replacement (TMVR) and systolic anterior motion (SAM)-associated MR. This review provides a comprehensive overview of the pathophysiology, risk assessment, and transcatheter interventions for mitigating the likelihood of LVOT obstruction in patients undergoing TMVR. In addition, it extends its focus to SAM-associated MR, elucidating the different aetiological mechanisms contributing to this phenomenon, beyond hypertrophic cardiomyopathy. Transcatheter treatment options, are explored as potential therapeutic strategies, offering insights into their hemodynamic effectiveness and limitations.

mitral regurgitation
transcatheter therapies
left ventricular outflow tract obstruction
Fig. 1.
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