†These authors contributed equally.
Background: Patients with secondary mitral regurgitation (sMR) often
present with greater mortality and comorbidity, which may be predicted by some
risk factors. This study was designed to investigate the prognostic meaning of
the echocardiographically detected wall motion score index (WMSI) in coronary
artery disease (CAD) patients with moderate or severe baseline sMR who underwent
percutaneous coronary intervention (PCI) therapy. Methods: The present
study was a multi-center and prospective cohort of consecutive CAD patients with
baseline moderate or severe sMR who underwent PCI. All underwent echocardiography
at baseline and at follow-up after PCI to assess sMR and WMSI. The primary
endpoint was the persistence of moderate or severe sMR after the second
echocardiographic measurement. Logistic and Cox proportional hazards models were
constructed for the primary (persistent moderate or severe sMR) and secondary
(worsening heart failure [HF]; all-cause mortality; cardiovascular-specific
mortality; and major adverse cardiovascular events [MACE]) endpoints.
Results: Among 920 participants, 483 had WMSI values of