IMR Press / RCM / Volume 24 / Issue 11 / DOI: 10.31083/j.rcm2411321
Open Access Review
High-Density Lipoprotein and Heart Failure
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1 Department of Cardiology, the Second Hospital of Shandong University, 250033 Jinan, Shandong, China
2 School of Clinical and Basic Medicine, Shandong First Medical University,250117 Jinan, Shandong, China
*Correspondence: (Ping Liu)
These authors contributed equally.
Rev. Cardiovasc. Med. 2023, 24(11), 321;
Submitted: 8 March 2023 | Revised: 13 June 2023 | Accepted: 21 June 2023 | Published: 21 November 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

The protective effect of high-density lipoprotein (HDL) on atherosclerosis is well known, and its mechanisms of action has been extensively studied. However, the impact of HDL on heart failure and its mechanisms are still controversial or unknown. The cardioprotective role of HDL may be reflected in its antioxidant, anti-inflammatory, anti-apoptotic, and endothelial function protection. In epidemiological studies, high-density lipoprotein cholesterol (HDL-C) levels have been negatively associated with heart failure (HF). The major protein component of HDL-C is apolipoprotein (Apo) A-I, while paraoxonase-1 (PON-1) is an essential mediator for many protective functions of HDL, and HDL may act through components like (Apo) A-I or PON-1 to delay heart failure progress. HDL can slow heart failure disease progression through parts like (Apo) A-I or PON-1. The potential causality between HDL and heart failure, the role of HDL in the pathogenesis of HF, and its interaction with C-reactive protein (CRP), triglycerides (TG), and monocytes in the process of heart failure have been briefly summarized and discussed in this article. HDL plays an important role in the pathogenesis, progression and treatment of HF.

high-density lipoprotein
high-density lipoprotein cholesterol
heart failure
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201602153/Clinical Medical Society and Technology Innovation Project of Jinan City
201602153/Science and Technology Innovation Project of Jinan City
202019193/Science and Technology Innovation Project of Jinan City
ZR2020MH041/Major Research and Development Project of Shandong Province
GG 201703080074/Natural fund project of Shandong Province
2021Szvup073/Central Government Guides Local Science and Technology Development
81170274/National Natural Science Foundation of China
82170462/National Natural Science Foundation of China
2021GXRC107/New 20 Measures for Universities in Jinan City funded by Jinan Municipal Science and Technology Project
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