IMR Press / RCM / Volume 23 / Issue 8 / DOI: 10.31083/j.rcm2308272
Open Access Review
Lipid Profile and Atrial Fibrillation: Is There Any Link?
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1 Department of Cardiology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, Jiangsu, China
2 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, Jiangsu, China
3 Department of Endocrinology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, Jiangsu, China
4 Cardiometabolic Center, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, China
*Correspondence: (Fei Hua); (Jian-Jun Li)
Academic Editors: Buddhadeb Dawn and Maurizio Pieroni
Rev. Cardiovasc. Med. 2022, 23(8), 272;
Submitted: 18 March 2022 | Revised: 26 May 2022 | Accepted: 14 June 2022 | Published: 26 July 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Atrial fibrillation (AF) is the most common type of symptomatic arrhythmias, which was induced by multiple causes and dyslipidemia is a well-known causal factor for the atherosclerotic cardiovascular disease (ASCVD). Interestingly, emerging data has suggested that lipid disorder may be also associated with AF. Several previous studies have shown a link of the prevalence of AF with decreased concentration of low-density lipoproteins (LDL)-cholesterol, total cholesterol (TC), high-density lipoproteins (HDL)-cholesterol, and elevated lipoprotein(a) [Lp(a)]. In this manuscript, we try to summarize the current evidence regarding the relation of dyslipidemia to the incident AF, present the potential lipid-related mechanisms of AF development, which is involved in cell membrane properties, LDL-receptors reduction, reverse cholesterol transport, adiposity-induced inflammation, apoptosis, and autophagy. Such information may boost our understandings concerning the lipid disorder and AF, which may help future exploration in the link of dyslipidemia and AF.

atrial fibrillation
lipid profile
Fig. 1.
82100328/National Natural Science Foundation of China
BK20210084/Natural Science Foundation of Jiangsu Province
2021K620C/Postdoctoral Foundation of Jiangsu Province
CZQM2020051/Young Talent Development Plan of Changzhou Health Commission
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