IMR Press / RCM / Volume 22 / Issue 2 / DOI: 10.31083/j.rcm2202037
Open Access Review
Non-high-density lipoprotein (non-HDL) cholesterol in adolescence as a predictor of atherosclerotic cardiovascular diseases in adulthood
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1 Department of Clinical Research, Scientific Writing Corp, Houston, TX 77054, USA
2 School of Medicine, Lahore Medical and Dental College, 531 Lahore, Pakistan
3 School of Medicine, Quaid-e-Azam Medical College, 63100 Bahawalpur, Pakistan
4 Department of Medicine, Kakatiya Medical College, 506009 Warangal, India
5 Department of Cardiology, Tabriz University of Medical Sciences, 5166614766 Tabriz, Iran
6 Department of Anesthesiology and Critical Care, Tabriz University of Medical Sciences, 5166614766 Tabriz, Iran
7 Department of Ophthalmology, Tabriz University of Medical Sciences, 5166614766 Tabriz, Iran
Rev. Cardiovasc. Med. 2021, 22(2), 295–299;
Submitted: 25 May 2021 | Revised: 22 June 2021 | Accepted: 23 June 2021 | Published: 30 June 2021

Defined as the total cholesterol minus high-density lipoprotein (HDL), non-HDL cholesterol has been increasingly acknowledged as a measure of risk estimation for developing atherosclerotic cardiovascular diseases (ASCVD). Comprising of apolipoprotein B100-containing cholesterols (very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), and lipoprotein (a) (Lp(a))), and apolipoprotein B48-containing lipoproteins (chylomicrons and its remnants), elevated serum levels of non-HDL cholesterol in early adolescence has been strongly linked with the development of ASCVD in adulthood. This article reviews the evidence from longitudinal studies, which demonstrate the cumulative risk of ASCVD in relation to the elevated levels of non-HDL cholesterol earlier in life.

High-density lipoprotein
Low-density lipoprotein
Atherosclerotic cardiovascular diseases
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