IMR Press / JIN / Volume 23 / Issue 3 / DOI: 10.31083/j.jin2303066
Open Access Review
Neuropeptides as Potential Biomarkers in Vascular Dementia
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1 Department of Traditional Chinese Medicine, Haikou Maternal and Child Health Hospital, 570102 Haikou, Hainan, China
2 Department of Rehabilitation, The Second Affiliated Hospital of Hainan Medical University, 570311 Haikou, Hainan, China
3 Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, 570311 Haikou, Hainan, China
4 Stomatological Hospital, Southern Medical University, 510280 Guangzhou, Guangdong, China
5 Department of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, 271000 Taian, Shandong, China
*Correspondence: (Yuzhen Xu)
J. Integr. Neurosci. 2024, 23(3), 66;
Submitted: 16 July 2023 | Revised: 1 October 2023 | Accepted: 9 October 2023 | Published: 21 March 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Neuropeptides are endogenous active substances within the central and peripheral nervous systems that play important roles in a wide range of brain functions, including metabolism, food intake, social behavior, reproduction, learning, sleep, and wakefulness. This article reviews recent advances in the involvement of neuropeptides in vascular dementia. Neuropeptides are present in the brain as chemical signals and last for nearly 50 years. Peptide hormones are chemical signals of the endocrine system. Thus, neuropeptides are the most diverse class of signaling molecules in the brain, involving the genomes of many mammals, encoding neuropeptide precursors and many bioactive neuropeptides. Here the aim is to describe the recent advances in classical neuropeptides, as well as putative neuropeptides from other families, in the control of or as diagnostic tools for vascular dementia. Additionally, its molecular mechanisms are described to explore new avenues of treatment and early diagnosis, as there is increasing evidence that dysregulation of vascular processes is associated with different pathological conditions.

vascular dementia
potential biomarker
202103070325/Shandong Medical and Health Technology Development Fund
M-2022216/Shandong Province Traditional Chinese Medicine Science and Technology Project
ZR2022MH124/Natural Science Foundation of Shandong Province
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