IMR Press / JIN / Volume 23 / Issue 3 / DOI: 10.31083/j.jin2303052
Open Access Original Research
The Genetic Association of MMP-2 Gene Polymorphisms with the Susceptibility to Alzheimer's Disease
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1 Department of Neurology, Science and Technology Innovation Park of the Fourth Affiliated Hospital of Harbin Medical University, 150028 Harbin, Heilongjiang, China
*Correspondence: (Lina Liu)
J. Integr. Neurosci. 2024, 23(3), 52;
Submitted: 31 August 2023 | Revised: 27 September 2023 | Accepted: 7 October 2023 | Published: 4 March 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: A hospital-based case-control study was carried out to elucidate the association of Matrix metalloproteinase-2 (MMP-2) gene candidate polymorphisms with the susceptibility to Alzheimer’s disease (AD) in the Chinese Han population. Methods: A total of 200 AD cases and an equal number of healthy controls were recruited to undergo genotyping of specific loci within the MMP-2 gene loci (rs243866, rs2285053, rs243865). Logistic regression analysis was applied to examine the association of the genotypes and alleles of MMP-2 gene polymorphisms with AD after adjusting clinical confounding factors. Results: Within AD group, a high proportion of rs243866 genotype carriers were found, and the difference remained significant despite adjusting for other clinical indicators. Among individuals with the rs243866 AA genotype and rs243865 TT genotype, the onset age of AD occurred at a younger age. Early-onset AD risk in rs243866 AA genotype carriers was 6.528 times higher than those in GG genotype carriers, and individuals with rs243865 TT genotype faced a 4.048-fold increased risk compared to those with CC genotype. Conclusions: MMP-2 gene rs243866 and rs243865 polymorphisms were closely associated with the onset age of AD. The presence of rs243866 AA genotype emerged as a crucial predictor of AD risk.

MMP-2 gene
single nucleotide polymorphism (SNP)
Alzheimer's disease
genetic predisposition
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