IMR Press / JIN / Volume 23 / Issue 2 / DOI: 10.31083/j.jin2302028
Open Access Review
Hibernation-Like Behavior Induced by 2-Methyl-2-Thiazoline and Its Organ-Protective Effects and Mechanisms
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1 Department of Anesthesiology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), 563000 Zunyi, Guizhou, China
2 Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, 563000 Zunyi, Guizhou, China
3 Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 563000 Zunyi, Guizhou, China
*Correspondence: (Tianyuan Luo); (Guihua Huang)
J. Integr. Neurosci. 2024, 23(2), 28;
Submitted: 13 June 2023 | Revised: 4 August 2023 | Accepted: 29 August 2023 | Published: 2 February 2024
Copyright: © 2024 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Hibernation is a prolonged state of low metabolism that animals enter in response to extreme environmental conditions to enhance their survival in harsh environments. Recent studies have shown that non-hibernating species can also be induced to enter a hibernation-like state. 2-methyl-2-thiazoline (2MT), a potent analog of fox odor, can induce fear-related behavior in mice with low body temperature and low metabolism, and has specific organ-protective effects. A systematic understanding of 2MT-induced hibernation and its underlying mechanisms may aid in expanding its applications in medicine and other fields.

hibernation state
organ protection
neural mechanisms
oxidative stress
82060653/National Natural Science Foundation of China
2020, No.257/Zunyi Science and Technology Planning Project
Fig. 1.
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