IMR Press / JIN / Volume 22 / Issue 6 / DOI: 10.31083/j.jin2206161
Open Access Original Research
Analysis of the Improvement Effect of Nervonic Acid Extracted from Xanthoceras Sorbifolium Bunge Oil on Antioxidant Response and Inflammatory Response in Parkinson's Disease
Dandong Hu1,2,3Yujuan Cui1,4Ji Zhang1,3,*
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1 School of Life Science, Northwest Normal University, 730070 Lanzhou, Gansu, China
2 Beijing Yanqing Market Supervision Inspection and Testing Monitoring Center, 102100 Beijing, China
3 Rural Development Academy, Northwest Normal University, 730070 Lanzhou, Gansu, China
4 Beijing Yanqing Center for Diseases Prevention and Control, 102100 Beijing, China
*Correspondence: (Ji Zhang)
J. Integr. Neurosci. 2023, 22(6), 161;
Submitted: 16 February 2023 | Revised: 11 April 2023 | Accepted: 25 April 2023 | Published: 6 November 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Objective: An extract of Xanthoceras sorbifolium Bunge (XSB) oil called nervonic acid (NA) was studied for its potential to ameliorate oxidative stress and inflammation in people living with Parkinson’s disease (PD). Recrystallization column chromatography was performed to isolate NA from the XSB oil. Twenty-five C57BL/6 mice (8–10 weeks old) were randomly assigned to one of five groups (control, model, low, medium, and high dosage). Methodology: Except for the control group, all of the experimental animals received an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The next phase was administering varied doses of NA produced from XSB oil to mice. Control, model, low-dose, medium-dose, and high-dose groups were created at random from SH-SY5Y and PC-12 cell cultures. Our study’s control groups exhibited typical normative conduct. Research: Polymerase chain reaction (PCR) was used to examine oxidative stress (OS) and inflammatory factors (IFs) in cells. By the time recrystallization column chromatography had finished its analysis, the concentration of NA had increased by a factor of roughly 26. Results: The model and high-dose groups showed similar levels of apoptosis in behavior (p > 0.05). All three NA treatment groups showed decreases in IFs and increases in superoxide dismutase (SOD) and GSH-Px mRNA (p < 0.05). NA, an antioxidant and anti-inflammatory chemical, has shown promising results in PD animal and cell models. Conclusions: NA synthesized from XSB oil will soon be available for use in the treatment of Parkinson’s disease. With the use of deep learning, patients will be able to arrest their health deterioration and enjoy an improved standard of living.

Parkinson's disease
Xanthoceras sorbifolium Bunge
nervonic acid
inflammatory factors
oxidative stress
Fig. 1.
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