IMR Press / JIN / Volume 22 / Issue 2 / DOI: 10.31083/j.jin2202031
Open Access Review
Research Progress of MicroRNAs in Spinal Cord Injury
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1 School of Medicine, Yan’an University, 716000 Yan'an, Shaanxi, China
*Correspondence: (Ya-Hui Chen)
J. Integr. Neurosci. 2023, 22(2), 31;
Submitted: 23 August 2022 | Revised: 5 November 2022 | Accepted: 17 November 2022 | Published: 14 February 2023
(This article belongs to the Special Issue Advances in Neurorehabilitation)
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Spinal cord injury is a serious and devastating condition. Recently, research into microRNAs (miRNAs) has become increasingly exhaustive and it has been determined that they are closely related to the pathophysiological processes of spinal cord injury. They participate in the regulation of the inflammatory response of spinal cord injury, the death of neuronal cells, and the repair of neural functions, which are related to the recovery of spinal cord injury. This review focuses on the relationship between miRNA and spinal cord injury, lists miRNA-324-5p, miRNA-221 and miRNA-124, which are helpful for the repair of spinal cord injury, and finally summarizes the current research progress of miRNA-based therapies, so as to provide a foundational reference for clinical and scientific researchers.

spinal cord injury
miRNA therapy
14JK1835/Shaanxi Provincial Education Department Project
Fig. 1.
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