Dear Colleagues,

During the past two decades, research has uncovered several forms of regulated cell death (RCD), which include necroptosis, pyroptosis, parthanatos, ferroptosis, cuproptosis, lysozincrosis, and disulfidptosis. RCD is critical for the development and homeostasis of almost all multicellular organisms. Dysregulation of RCD leads to diverse disease states. However, knowledge of the role of RCD in different diseases is still in its infancy. It is crucial to determine the detailed mechanisms by which various types of RCD play a role in the pathogenesis of diseases. Accumulating evidence supports the pharmacological modulation of RCD as a therapeutic target for diseases.

The aims of this research topic are:

  (1) To delineate the role of RCD in various diseases, including cancers and non-cancerous diseases.
  (2) To uncover novel therapy regimens by targeting RCD.

We welcome submissions of original research, reviews, mini-reviews, and systematic reviews that explore a wide range of topics that include, but are not limited to, the following:

• How dysregulation of RCD leads to pathogenesis of diseases
• How epigenetic and post-translational modifications regulate RCD to cause diseases
• How the interplay of different types of RCD contribute to diseases
• How the interplay of cell signaling pathways, such as cGAS-STING, in different RCDs, contribute to diseases
• Strategies for targeting RCD to treat diseases

Prof. Hongquan Wang, Lida Du and Yumin Wang
Guest Editors