- Academic Editors
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Background: Autoimmune disorders are more common in premature ovarian
insufficiency (POI) than in the general population. The most important
association is with autoimmune Addison’s disease. Measurement of adrenocortical
antibodies (ACA) and/or 21-hydroxylase antibodies (21-OH) is recommended in every
POI patients as they appear to be the marker with the highest diagnostic
sensitivity for autoimmune POI. Also thyroid peroxidase autoantibodies (TPO-Ab)
should be assayed due to the common association between thyroid disease and POI.
The underlying etiologies of diminished ovarian reserve (DOR) in young women can
be expected to be similar to the etiology of POI since they represent a continuum
in the phenotypic expression of premature ovarian aging. Methods: This
pilot case-control study was conducted between January 2019 and April 2020. The
study group consisted of patients under the age of 35, who was infertile and
diagnosed with idiopathic DOR by ovarian reserve tests during infertility work
up. Controls were patients of the same age range who diagnosed with isolated
tubal factor or male infertility and had functional ovarian reserve test results
during infertility work up. Patients with a history of ovarian surgery, cancer,
genetic or autoimmune disease were excluded. Abnormal ovarian reserve tests are
defined as antral follicle count