Background: Choriocarcinoma is a curable malignant neoplasm when
chemotherapy is properly implemented. However, when chemotherapy resistance
occurs, disease can be fatal. Misdiagnosis is common, which may lead to delaying
of the first cycle of chemotherapy and increase the possibility of
chemoresistance. Methods: We analyzed 36 choriocarcinoma cases who were
treated in our department about their clinical characteristics, and their
diagnosis and treatment processes together with the serum -hCG
variation. Results: Analysis showed that the disease onset age, FIGO (International Federation of Gynecology and Obstetrics)
stage distribution were similar to the other cohort. The primary origins were
uterine canals, and the serum -hCG elevated with or without vaginal
bleeding were common, which all easily lead to misdiagnosis of benign pregnancy
related diseases. Our data demonstrated that the misdiagnosis of choriocarcinoma
resulted in delaying of the first cycle of chemotherapy, followed by decreased
control of serum -hCG after one chemotherapy cycle and more cycles for
serum -hCG normalization, which meant the possibility of generating
chemoresistance. Conclusions: In summary, standardized surveillance and
treatment process to decrease misdiagnosis rate of choriocarcinoma can be an
effective measure to improve the prognosis of patients.