IMR Press / CEOG / Volume 49 / Issue 10 / DOI: 10.31083/j.ceog4910225
Open Access Original Research
Relationship between MUC17 Gene Polymorphisms and Endometriosis in Central Plains Chinese Women
Show Less
1 Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, Henan, China
2 Department of Ultrasound, Zhengzhou Central Hospital, 450001 Zhengzhou, Henan, China
*Correspondence: yangli0727@zzu.edu.cn (Li Yang)
Academic Editor: Qian Zhong
Clin. Exp. Obstet. Gynecol. 2022, 49(10), 225; https://doi.org/10.31083/j.ceog4910225
Submitted: 24 June 2022 | Revised: 26 June 2022 | Accepted: 27 July 2022 | Published: 22 September 2022
(This article belongs to the Special Issue Endometriosis)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: Endometriosis is one of the common benign gynecological diseases among reproductive aged women, which almost lead to pelvic pain, infertility and menstrual disorders. There is no blood test available for the diagnosis of endometriosis. MUC17 has been revealed to play a role in a variety of cancers, but the role of MUC17 single nucleotide polymorphisms (SNPs) in endometriosis susceptibility remains unclear. Methods: In the present study, genotyping for four MUC17 polymorphisms in 117 endometriosis patients and 118 female control participants was undertaken using the Agena Mass ARRAY. An unconditional logistic regression model was used to estimate the role of MUC17 gene polymorphisms in endometriosis. Results: Bioinformatics analysis showed that rs6966570 could be relevant to the transcription factor binding sites of proteins bound and was related to expression quantitative trait Loci (eQTL) and Motifs. Rs10246021 affected eQTL and Motifs. Nevertheless, there was no significant difference in the frequency of mutation of MUC17 gene between the case group and the control group (p > 0.05), the C allele of rs11979706 (OR: 0.37; 95% CI: 0.18–0.74; p: 0.03), the T allele of rs10246021 (OR: 0.43; 95% CI: 0.21–0.88; p: 0.018), the T allele of rs6966570 (OR: 0.45; 95% CI: 0.22–0.92; p: 0.026), and the T allele of rs4729655 (OR: 0.48; 95% CI: 0.26–0.88; p: 0.017) may be protective factors for the occurrence of dysmenorrhea in endometriosis. Logistic regression analysis indicated genotypes MUC17 rs11979706 CC and rs4729655 TT contribute a lower risk to dysmenorrhea (p = 0.024, p = 0.034), respectively. Haplotype analysis showed that individuals with CTTT haplotypes had a lower risk of developing dysmenorrhea (p = 0.008). In the log-additive model, the rs4729655 was associated with endometriosis-induced infertility. Conclusions: On the whole, these findings demonstrate that MUC17 gene polymorphisms was not correlated with endometriosis susceptibility but was associated with secondary dysmenorrheal and infertility in Central Plains Chinese women.

Keywords
endometriosis
MUC17
single nucleotide polymorphisms
dysmenorrhea
Figures
Fig. 1.
Funding
2018020215/ National Health and Family Planning Commission of Henan Province
Share
Back to top