†These authors contributed equally.
Academic Editor: Giuseppe Ricci
Background: Despite the active
researches recently conducted into the relationship between 1-h postload glucose
(1-h PG) during standard oral glucose tolerance test and future risk of type 2
diabetes, research regarding the clinical capacity of 1-h PG to assess insulin
resistance in those with polycystic ovary syndrome (PCOS) is still insufficient.
The purpose of this study was to investigate the optimal 1-h PG cutoff value to
identify insulin resistance in women with PCOS. Methods: One hundred
fifty-three women aged 18 to 35 years who were diagnosed with PCOS were enrolled
in this study. Insulin resistance was defined as having abnormal insulin
sensitivity or hyperglycemia. Spearman’s rank correlation coefficient and
receiver operating characteristic (ROC) curve analyses were conducted to assess
the relationship between 1-h PG and other parameters and to determine the optimal
1-h PG cutoff for identifying insulin resistance, respectively. Results:
Significant correlations were observed between 1-h PG, 2-h PG and fasting
glucose, and other fasting-state insulin sensitivity assessment indices, other
than fasting insulin level. The optimal 1-h PG threshold value for identifying
insulin resistance was 138.5 mg/dL. Categorization of patients based on the 1-h
PG threshold showed significant differences for all laboratory variables related
to insulin sensitivity/resistance, other than fasting insulin.
Conclusions: Our results suggest that a 1-h PG value of