Sheehan syndrome, which is defined as hypopituitarism, is usually caused by massive postpartum hemorrhage. Hormone replacement therapy is recommended in patients with Sheehan syndrome. It is rare that pregnancy occurs in a patient with Sheehan syndrome, which is associated with high risk of maternal and fetal mortality. The authors report a 36-year-old twin pregnancy with Sheehan syndrome after the first pregnancy. She was treated with adequate management by obstetrician and endocrinologist cooperation during the pregnancy and delivery and had a successful outcome of this pregnancy. This case highlights the importance of proper management for the outcome of pregnancy in patients with Sheehan syndrome.